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98 results

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Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents.
Yoon YS, Hwang HJ, Kim JM, Chung KS, Jang SY, Heo SW, Lee SY, Kim SY, Song HA, Hong SJ, An HJ, Park SW, Im JJ, Oh DH, Lee AR, Lee KT. Yoon YS, et al. Biomed Pharmacother. 2023 Jul;163:114708. doi: 10.1016/j.biopha.2023.114708. Epub 2023 Apr 28. Biomed Pharmacother. 2023. PMID: 37121153 Free article.
Therefore, the aim of the present study was to evaluate whether DW-1021, the ionic complex of pelubiprofen (NSAID) and tramadol (opioid), has synergic antinociceptive and anti-inflammatory effects in nociceptive as well as inflammation-induced nociceptive models compared t …
Therefore, the aim of the present study was to evaluate whether DW-1021, the ionic complex of pelubiprofen (NSAID) and tramadol (opio …
Effect of Sodium Valproate and Docosahexaenoic Acid on Pain in Rats.
Kunder SK, Bairy LK, Arivazhahan A. Kunder SK, et al. J Clin Diagn Res. 2017 Mar;11(3):FF05-FF08. doi: 10.7860/JCDR/2017/25036.9596. Epub 2017 Mar 1. J Clin Diagn Res. 2017. PMID: 28511406 Free PMC article. Review.
Group I was control (distil water 1 ml/kg), Group II received intraperitoneal injection of tramadol (10 mg/kg), Group III, IV, V were injected intraperitoneal sodium valproate 100, 200, 400 mg/kg with distil water respectively and Group VI, VII, VIII were given sodium valp …
Group I was control (distil water 1 ml/kg), Group II received intraperitoneal injection of tramadol (10 mg/kg), Group III, IV, V were …
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Huang H, Wang W, Xu X, Zhu C, Wang Y, Liu J, Li W, Fu W. Huang H, et al. Eur J Med Chem. 2020 Mar 1;189:112070. doi: 10.1016/j.ejmech.2020.112070. Epub 2020 Jan 18. Eur J Med Chem. 2020. PMID: 31982651
Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made. In this work, starting from Tramadol, a series of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxamide derivatives were designed and syn …
Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made. In this work, starting from …
Effect of Surgical-Site, Multimodal Drug Injection on Pain and Stress Biomarkers in Patients Undergoing Plate Fixation for Clavicular Fractures.
Yoo JS, Heo K, Kwon SM, Lee DH, Seo JB. Yoo JS, et al. Clin Orthop Surg. 2018 Dec;10(4):455-461. doi: 10.4055/cios.2018.10.4.455. Epub 2018 Nov 21. Clin Orthop Surg. 2018. PMID: 30505414 Free PMC article.
In patients who wanted further pain control or had a VAS pain score of 7 points until POH 72, 75 mg of intravenous tramadol was administered, and the intravenous tramadol requirements were also recorded. ...RESULTS: The SI group showed significantly lower VAS pain s …
In patients who wanted further pain control or had a VAS pain score of 7 points until POH 72, 75 mg of intravenous tramadol was admin …
Molecular Insights into the In Vivo Analgesic and Anti-Inflammatory Activity of Indomethacin Analogues.
Ahmad AA, Hussain K, Shah MR, Ashhad Halimi SM, Rabbi F, Ahmad Z, Khan I, Rauf A, Alshammari A, Alharbi M, Rasul Suleria HA. Ahmad AA, et al. ACS Omega. 2023 Aug 10;8(33):30048-30056. doi: 10.1021/acsomega.3c02033. eCollection 2023 Aug 22. ACS Omega. 2023. PMID: 37636936 Free PMC article.
The pharmacological screening revealed that test compounds 2a-2f had a superior peripheral analgesic effect at a dose of 10 mg/kg, in comparison to the parent drug indomethacin, while compound 2g exhibited slightly lower activity at the same dose. The hot plate results sho …
The pharmacological screening revealed that test compounds 2a-2f had a superior peripheral analgesic effect at a dose of 10 mg/kg, in compar …
Trends and risk factors for opioid administration for non-emergent lower back pain.
Gwam CU, Emara AK, Chughtai N, Javed S, Luo TD, Wang KY, Chughtai M, O'Gara T, Plate JF. Gwam CU, et al. World J Orthop. 2021 Sep 18;12(9):700-709. doi: 10.5312/wjo.v12.i9.700. eCollection 2021 Sep 18. World J Orthop. 2021. PMID: 34631453 Free PMC article.
The most common opioids prescribed over the period included hydrocodone-based medications (49.1%) and tramadol-based medications (16.9), with the combination of all other opioid types contributing to 35.7% of total opioids prescribed. ...
The most common opioids prescribed over the period included hydrocodone-based medications (49.1%) and tramadol-based medications (16. …
Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives.
Bibi H, Nadeem H, Abbas M, Arif M. Bibi H, et al. BMC Chem. 2019 Jan 29;13(1):6. doi: 10.1186/s13065-019-0518-6. eCollection 2019 Dec. BMC Chem. 2019. PMID: 31355366 Free PMC article.
These compounds were characterized by FTIR, (1)HNMR, (13)CNMR and elemental analysis data and screened for their analgesic activity using acetic acid-induced writhing assay and hot plat test in mice and compared with the standard centrally acting analgesic, tramadol. RESUL …
These compounds were characterized by FTIR, (1)HNMR, (13)CNMR and elemental analysis data and screened for their analgesic activity using ac …
Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot-plate and tail-flick tests.
Cannon CZ, Kissling GE, Hoenerhoff MJ, King-Herbert AP, Blankenship-Paris T. Cannon CZ, et al. Lab Anim (NY). 2010 Nov;39(11):342-51. doi: 10.1038/laban1110-342. Lab Anim (NY). 2010. PMID: 20962760
Tramadol is an opioid-like analgesic with relatively mild side effects. ...Results from the hot-plate and tail-flick tests for rats that were given tramadol p.o. were similar before and after administration, regardless of tramadol dosage, suggesting th …
Tramadol is an opioid-like analgesic with relatively mild side effects. ...Results from the hot-plate and tail-flick tests for …
Effects of Early Weight-Bearing Treadmill Training Combined with Pre-Emptive Analgesia on Femoral Fracture Recovery.
Chen Y, Ouyang J, Chen H. Chen Y, et al. Evid Based Complement Alternat Med. 2023 Jan 31;2023:8498062. doi: 10.1155/2023/8498062. eCollection 2023. Evid Based Complement Alternat Med. 2023. PMID: 36760470 Free PMC article. Retracted.
Oblique plate test was accomplished to assess hindlimb motor function recovery of rats in each group. Status of fracture healing was assessed through digital radiography (DR). Hematoxylin-eosin (HE) staining and immunohistochemistry of bone morphogenetic protein-2 ( …
Oblique plate test was accomplished to assess hindlimb motor function recovery of rats in each group. Status of fracture healing was …
Post-operative analgesia following TPLO surgery: A comparison between cimicoxib and tramadol.
Piras LA, Mancusi D, Olimpo M, Gastaldi L, Rosso V, Panero E, Staffieri F, Peirone B. Piras LA, et al. Res Vet Sci. 2021 May;136:351-359. doi: 10.1016/j.rvsc.2021.03.010. Epub 2021 Mar 13. Res Vet Sci. 2021. PMID: 33773391 Free article.
CONCLUSIONS AND CLINICAL RELEVANCE: A significant difference was not found in long-term postoperative analgesia provided by cimicoxib or tramadol in dogs undergoing TPLO when subjective parameters (with the exception of knee joint range of motion) were evaluated, but use o …
CONCLUSIONS AND CLINICAL RELEVANCE: A significant difference was not found in long-term postoperative analgesia provided by cimicoxib or …
98 results